What are polynucleotides and how do they work?

Polynucleotides are naturally occurring chains of nucleotides—the building blocks of DNA and RNA. In regenerative medicine, purified polynucleotides derived from salmon or trout DNA are injected into the skin to promote cell renewal, reduce inflammation, and restore skin structure at a cellular level.

They act as:

• Tissue regenerators by encouraging fibroblast activity (the cells that produce collagen and elastin)
• Anti-inflammatory agents that calm redness and oxidative stress
• Hydrators by attracting water molecules and improving skin moisture

This makes polynucleotides ideal for aging, sensitive, or sun-damaged skin.

How do polynucleotides repair skin at the DNA level?

Polynucleotide molecules support DNA repair and regeneration in several ways:

• They stimulate the skin’s repair response by mimicking damaged cell signals
• They reduce oxidative stress caused by UV radiation and pollution
• They activate fibroblasts to rebuild collagen and elastin networks

Because they are biologically compatible, the skin recognizes polynucleotides as healing signals, helping damaged tissues restore structure, thickness, and elasticity.

This DNA-level regeneration is what sets them apart from hyaluronic acid or vitamin-based injectables.

What skin concerns can polynucleotides address?

Polynucleotide therapy can treat a wide variety of skin issues, including:

• Fine lines and wrinkles
• Dehydrated or dull skin
• Acne scarring
• Post-inflammatory pigmentation
• Redness, rosacea, or sensitivity
• Thin or sagging skin (especially under eyes and cheeks)
• UV or environmental skin damage

LegacyMD patients often choose polynucleotide therapy as a powerful add-on or standalone solution for long-term skin rejuvenation.

How is polynucleotide treatment performed?

At LegacyMD, polynucleotide injections are administered in a clinical setting under the supervision of Dr. Hernandez Loy. The process includes:

1. Initial skin consultation to determine suitability
2. Cleansing and numbing the area
3. Microinjections of polynucleotide gel into the dermis
4. Optional combination with microneedling or laser for enhanced delivery

The entire session takes about 30–45 minutes. Treatment is usually recommended in a series of 2–3 sessions spaced 2–4 weeks apart.

What results can I expect and when?

Patients typically notice improvements in skin texture, elasticity, and hydration within 7–10 days. Full effects build over several weeks and peak after the final session.

You may expect:

• Brighter, smoother skin tone
• Reduction in fine lines
• Less redness and irritation
• Long-lasting skin thickening and resilience

Results may last 6–12 months, especially when combined with sun protection and proper skincare.

How much does polynucleotide therapy cost?

At LegacyMD, polynucleotide injections are offered at $425 per session. Package pricing may be available for patients completing a full treatment plan of 2–3 sessions.

Pricing includes:

• Consultation with Dr. Hernandez Loy
• Medical-grade polynucleotide injectable
• Numbing and clinical preparation
• Follow-up care and skincare guidance

Compared to fillers or lasers, polynucleotides offer long-term structural improvements at a highly competitive rate.

Who is a good candidate for DNA repair therapy?

You may be a candidate for polynucleotide treatment if you:

• Have sensitive, reactive, or rosacea-prone skin
• Struggle with sun damage or hyperpigmentation
• Want to treat thin or crepey skin around the eyes
• Are seeking a natural skin enhancer instead of fillers
• Wish to prep or recover from resurfacing or peel treatments

It’s safe for most skin types and tones, though not recommended during active infections or pregnancy.

Are there any side effects or downtime?

Polynucleotide therapy is well tolerated. Side effects are minimal and temporary:

• Mild redness or swelling at injection sites
• Slight bruising or tightness
• Rarely, skin sensitivity for 1–2 days

Most patients return to normal activities the same day. It’s advised to avoid intense workouts or sun exposure for 24 hours.

Why Choose LegacyMD for Polynucleotide Skin Rejuvenation?

LegacyMD is a leader in advanced regenerative skincare across Coral Gables, West Miami, and Westchester. Dr. Hernandez Loy brings deep expertise in polynucleotide therapy and integrative dermatology.

What sets us apart:

• FDA-cleared polynucleotide formulations
• Personalized protocols for every skin type
• Combination strategies (e.g., with exosomes, PRP, peels)
• Medical-grade safety and supervision
• Concierge-level support before and after treatment

Our patients aren’t just getting aesthetic results—they’re experiencing deep cellular repair and long-term rejuvenation.